Functional MRI of cognitive control in autism

Functional MRI of cognitive control in autism - NeuroImaging of Cognitive control in Autism (NICA)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35416

Enrollment

300

Registered

2006-09-19

Start date

2008-05-25

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autism

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria: - 6-16 years ;Inclusion criteria for subjects with autism: - DSM-IV diagnosis of autism, according to diagnostic interview (ADI-R);Inclusion criteria for controls: - no DSM-IV diagnosis according to diagnostic interview (DISC) - no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) - IQ>70

Exclusion criteria

Exclusion criteria: - history or presence of major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system - presence of metal objects in or around the body (pacemaker, dental braces) - history or presence of neurological illness

Design outcomes

Primary

Measure	Time frame
The primary outcome measure in the fMRI studies will be MR signal. This signal represents the activation level (compared to a control condition) and is hypothesized to differ in fronto-striatal regions between children with autism and control children. A second, behavioral outcome measure is performance (reaction times and accuracy) on the cognitive controls tasks. The primary outcome measure for the DTI-scans will be anisotropy (representing the unequal regional diffusion of water), which is a measure of regional white matter regularity. Finally the primary outcome measure of the exploratory genetic studies will also be MR signal, which we hypothesize will differ in fronto-striatal regions between groups with different genetic profiles.	—

Measure

Time frame

The primary outcome measure in the fMRI studies will be MR signal. This signal represents the activation level (compared to a control condition) and is hypothesized to differ in fronto-striatal regions between children with autism and control children. A second, behavioral outcome measure is performance (reaction times and accuracy) on the cognitive controls tasks. The primary outcome measure for the DTI-scans will be anisotropy (representing the unequal regional diffusion of water), which is a measure of regional white matter regularity. Finally the primary outcome measure of the exploratory genetic studies will also be MR signal, which we hypothesize will differ in fronto-striatal regions between groups with different genetic profiles.

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Countries

Netherlands

Outcome results