deep (third degree) burn wounds
Conditions
Interventions
Within the first few day after admission to the burn centre a biopsy (approx. 3
cm2) is taken from the unaffected skin and taken to the lab for the culture of
the keratinocytes. After two weeks the
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -competent and temporarily incompetent patients 18 years of age or older with acute burn wounds that require widely meshed skin grafting, which do not need immediate excision - minimal study wound area 100 cm2 - maximal study wound area 300 cm2 - maximal TBSA 50% full thickness wounds -Informed consent
Exclusion criteria
Exclusion criteria: - Immunocompromised patients - Infected wounds - Use of high doses of (.20mg/pd) corticosteroids and/or cytostatica - Known penicillin allergy - Conditions where the patient is non compliant as judged by a medical specialist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The % of wound closure after 7 days. Wound closure will be monitored by an experienced surgeon. The exact area will be assessed using computerized planimetric determination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Scar quality at three and 12 months after operation will be assessed using the POSAS, cutometer to measure scar elasticity, dermaspectometer to assess scar colour and Primos 3D to assess the smoothness of the scar. | — |
Countries
Netherlands
Outcome results
None listed