Multiple myeloma and Kahler's disease
Conditions
Interventions
None listed
Sponsors
Hematologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient with a positive FDG-PET scan. Patients with relapsing multiple myeloma according to international defined guidelines.;Relapse after having achieved complete remission. 1. Reappearance of paraprotein 2. More than 5% plasma cells in bone marrow. 3. New lytic lesions or progression of old lesions. 4. New hypercalceamia.;Relapse after having achieved partial remission 1. Increases of paraprotein with more than 25% 2. Increase of urine paraprotein with more than 25% 3. Increase of plasma cells in bone marrow with 10% 4. New lytic lesions or progression of old lesions 5. New hypercalceamia
Exclusion criteria
Exclusion criteria: - Radiotherapy in the last 3 months. - Ineligible to lay supine during the PET scan. - Age =250 µM.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of 18F-FAZA scans in patients with relapsing multiple myeloma. In addition bone marrow staining to demonstrate whether hypoxia related proteins are upregulated by plasma cells or surrounding cells including HIF 1a , HIF2a , GLUT-1 and -3 and VEGF. | — |
Secondary
| Measure | Time frame |
|---|---|
| not applicable. | — |
Countries
Netherlands
Outcome results
None listed