beroerte stroke
Conditions
Interventions
The training is performed at home with a computer/display system that manages
the training (stimuli) and controls the eye fixation by the patient (using a
webcam). When the patient breaks fixation t
day 2: Behavior/perception
day 3: Behavior/perception). Each test-day
comprises on average 2 hours of measurements.
Patients will undergo standard perimetrical tests to map out the visual field.
Eye fixation is monitored dur
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Visual field defect as result of stroke; chronic stroke patients (post onset time > 10 months); age between 18 and 75 years; ability to fixate eyes on a stationary point; capability of sustained concentration to perform training.
Exclusion criteria
Exclusion criteria: visual neglect; MRI contra-indications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-Pre differences in the measured variables (perimetry = subjective extent of the visual field; fMRI = objective extent of the visual field; structural MRI = connectivity between visual cortical areas; driving performance in the simulator; reading test) all provide an effect parameter of the full training (control and test training). These effect pairs collected for the 4 groups of subjects allow for univariate analysis of the main dimensions of the experiment: training (test or control) and training stimulus type (flow and points) and their interactions. The effects of the control training (of the intact field) by itself and the test training (of the field defect) by itself are derived from Intermediate-Pre differences and Post-Intermediate differences. These differences are collected for each patient and thus allow for comparing between the two types of training on the effect parameters (perimetry, MRI measures, driving) using t-tests based on the full group size of 40 patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes of this study are threefold: (1) QoL questionnaires and (G)oal (A)ttainment (S)caling eveluate the change in daily life performance following the training (2) Evaluation of the trainingdata will provide insight in the frequency of fixation loss during training and the change of the visual field defect during the training; this may extend our insight into optimal duration of training. (3) Loci with marked reduction of the field defect will be used to seek for correlates in the structural MRI data prior to training, pointing e.g. to special connectivity between intact field loci in higher visual cortex and corresponding damaged visual cortical areas; and to seek for activity that corresponds to areas that are subjectively blind prior to the training (i.e. discrepancies between objective and subjective perimetry). This may help to establish the odds of training outcome from MRI data prior to training. | — |
Countries
Netherlands
Outcome results
None listed