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Steatosis of the liver in adolescents born small for gestational age (SGA) after prolonged growth hormone treatment for small stature.

Steatosis of the liver in adolescents born small for gestational age (SGA) after prolonged growth hormone treatment for small stature. - Liver steatosis in growth hormone treated adolescents born SGA.

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON35362
Enrollment
20
Registered
2010-05-17
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fatty liver NAFLD

Interventions

None listed

Sponsors

Universitair Medisch Centrum Groningen
Lead Sponsor

Eligibility

Age
12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Group 1. 1. Adolescents, born SGA (birth weight or length less than -2 SDS for gestational age). 2. Growth hormone treatment because of short stature (no catch-up growth). 3. Near-final height (height velocity less than 1 cm during the last 6 months or less than 2 cm during the last year). Group 2. 1. Adolescents born SGA, without catch-up growth. 2. No growth hormone treatment. 3. (Near-)final height less than -2 SDS.

Exclusion criteria

Exclusion criteria: Disorders other than SGA influencing growth.

Design outcomes

Primary

MeasureTime frame
Primary outcome is hepatic fat content measured by MRS and echography.—

Secondary

MeasureTime frame
Secundary outcome is the relationship between hepatic fat content and: • time and total dose of the growth hormone treatment • insulin sensitivity • adipose tissue distribution—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)