Regulation of prothrombotic factors in blood of type II diabetes mellitus patients

Regulation of prothrombotic factors in blood of type II diabetes mellitus patients - Clopi2007

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35350

Enrollment

Registered

2008-01-15

Start date

2009-01-07

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus / diabetes

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: [1] matched controls [2] DMII patients taking insulin [3] DMII patients taking insulin and clopidogrel [4] DMII patients taking oral bloodglucose lowering drugs (biguanides or sulfonylurea derivatives) [5] DMII patients taking oral bloodglucose lowering drugs (biguanides or sulfonylurea derivatives) and clopidogrel

Exclusion criteria

Exclusion criteria: Pregnancy Use of anti-epileptic drugs Use of acetyl salicylic acid or other non-steroidal anti-inflammatory drugs

Design outcomes

Primary

Measure	Time frame
Part 1 (study on platelets) [1] Is it possible to identify clopidogrel resistant patients by aggregation studies? [2] Is it possible to explain this resistance by a difference in one of the components in the P2Y12 signalling cascade? [3] Why does insulin resistance leads to differences in P2Y12 signalling? Part 2 (study on monocytes) [1] Do monocytes of DMII patients have a normal inhibiton of tissue factor production by insulin? [2] What is the cause of insulin resistance in DMII monocytes? [3] Is the P2X7 receptor a possible target for interference of tissue factor production?	—

Measure

Time frame

Part 1 (study on platelets) [1] Is it possible to identify clopidogrel resistant patients by aggregation studies? [2] Is it possible to explain this resistance by a difference in one of the components in the P2Y12 signalling cascade? [3] Why does insulin resistance leads to differences in P2Y12 signalling? Part 2 (study on monocytes) [1] Do monocytes of DMII patients have a normal inhibiton of tissue factor production by insulin? [2] What is the cause of insulin resistance in DMII monocytes? [3] Is the P2X7 receptor a possible target for interference of tissue factor production?

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Countries

Netherlands

Outcome results