coagulation Thrombocyte function
Conditions
Interventions
The only intervention in volunteers is the drawing of 12 ml of whole blood via
venipuncture. Intervention will take place in vitro: Incubation will be
performed with lidocaine at concentrations betw
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers, aged 18-65, ASA status I.
Exclusion criteria
Exclusion criteria: History of abnormal bleeding, ingestion of coagulation imparing drugs, pre-existing disease of heart, lungs, vessels, kidneys or liver.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is thrombocyte aggregation in vitro in the ASPItest of MultiPlate, expressed as Area under the Curve (AUC). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives of the study are results from three other complementary tests using MultiPlate, i.e. the TRAPtest and COLtest, which both test the potential of activation of thrombocytes, and the ADP-test, which tests for thrombocyte impairment via the ADP pathway (e.g., clopidogrel). | — |
Countries
Netherlands
Outcome results
None listed