The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection: Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections

The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection: Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections - SNOT'R

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35329

Enrollment

400

Registered

2006-09-18

Start date

2006-10-15

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Innate immune response Viral respiratory tract infection

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Child = under the age of 13 months (exception:

Exclusion criteria

Exclusion criteria: Child = previous airway morbidity or severe co-morbidity (exception: no exclusion criteria for group 3) Adult = None

Design outcomes

Primary

Measure	Time frame
1. Disease severity: Children: Standardised Respiratory Distress Assessment Instrument (RDAI) Score Elderly: Standardised Adult Physiology And Chronic Health (APACHE) Score, Respiratory Parameter 2. Virological analysis (nasopharyngeal material): Quantitative RT-PCR on RSV, hMPV, rhinovirus, adenovirus, PIV 1-4, Flu A en B, en coronavirus 3. Immunological analysis/cytokine concentrations (nasopharyngeal material): Interferon-alfa using commercial ELISA IL-1aβ/a, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12*70, IL-13, IL-15, IL-17, IL-18, IFN-γ and TNF-a using Luminex 4. Immunological analysis (blood): Leucocytes and differentiation Immunophenotyping Toll-like receptor responses	—

Measure

Time frame

1. Disease severity: Children: Standardised Respiratory Distress Assessment Instrument (RDAI) Score Elderly: Standardised Adult Physiology And Chronic Health (APACHE) Score, Respiratory Parameter 2. Virological analysis (nasopharyngeal material): Quantitative RT-PCR on RSV, hMPV, rhinovirus, adenovirus, PIV 1-4, Flu A en B, en coronavirus 3. Immunological analysis/cytokine concentrations (nasopharyngeal material): Interferon-alfa using commercial ELISA IL-1aβ/a, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12*70, IL-13, IL-15, IL-17, IL-18, IFN-γ and TNF-a using Luminex 4. Immunological analysis (blood): Leucocytes and differentiation Immunophenotyping Toll-like receptor responses

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Countries

Netherlands

Outcome results