glioblastoma multiforme (GBM) malignant brain tumor
Conditions
Interventions
Randomization in the iMRI or cNN group, after which treatment will be given as
desribed in the summary paragraph "Study Design". Before and after surgery the
patient will be requested to fill in som
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * supratentorial brain tumor, on contrast enhanced dMRI suspected to be GBM * indication for gross total resection (GTR) of the tumor * age *18 years * WHO Performance Scale * 2 * ASA class * 3 * adequate knowledge of the Dutch or French language * informed consent
Exclusion criteria
Exclusion criteria: - recurrent brain tumor - multiple brain tumor localizations - earlier skull radiotherapy - earlier chemotherapy for GBM - Chronic Kidney Disease or other renal function disorder - known MR-contrast allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For each treatment group the percentage of residual tumor as visible on the postoperative scan will be compared to tumor volume on the preoperative scan. The main question from the RACING-project is whether iMRI helps to achieve a lower percentage of residual tumor volume compared to cNN. | — |
Secondary
| Measure | Time frame |
|---|---|
| * complications * clinical performance (WHO Performance Scale) / quality of life * survival | — |
Countries
Netherlands
Outcome results
None listed