arteriosclerosis coronary heart disease
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group A: 1) Healthy individuals aged between 18 and 45 years old. 2) Not known with any clinical significant disease 3) Not using any prescription medication 4) Non-smoking Group B: 1) Patients aged equal to or greater than (*) 45 years. 2) Known with an elevated LDL cholesterol (LDL > 90th percentile) with or without LDLc lowering therapy
Exclusion criteria
Exclusion criteria: Group A and B: ;1) Current active inflammatory diseases. 2) Any clinically significant medical condition that could interfere with the conduct of the study. 3) Known with hypertension (>15 years) , cardiac hypertrophy, cardiac failure (NYHA class I-IV) or any form of ischemic heart disease. 4) Standard contra-indications to MRI. 5) Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. 6) Contra-indications to salbutamol and / or nitroglycrine;For group A only: 1) Previous clinical significant vaccination reactions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The absolute difference between baseline endothelial shear stress before and after an endothelial dependent and independent vasodilator. | — |
Secondary
| Measure | Time frame |
|---|---|
| The association between the absolute flow-mediated vasodilatation (mm) in the brachial artery and endothelial shear stress in N/m2. Tertiary outcome: The association between the absolute flow-mediated vasodilatation in the brachial artery and endothelial shear stress in N/m2 during an inflammatory respons. . | — |
Countries
Netherlands
Outcome results
None listed