bloedruk en orgaandoorbloeding na hartstilstand cardiac arrest organ blood flow
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Informed consent - Age >= 18 years - Out of hospital cardiac arrest - Initial rhythm on arrival of the ambulance ventricular fibrillation or non-perfusion ventricular tachycardia or a presumed cardiac origin of the arrest - Glasgow coma score upon arrival at the hospital of 8 or less - Indication for mild therapeutic hypothermia
Exclusion criteria
Exclusion criteria: - Comatose state before cardiac arrest or known neurological disease - Cardiogenic shock, defined as mean arterial pressure less than 60 mmHg and/or urine production 200 µmol/ml), chronic liver failure - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study endpoint is the change in blood viscosity in time during hypothermia and subsequent rewarming. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are - Hemodynamic changes, such as heart rate, blood pressure, cardiac output, central venous pressure, pulse pressure variation (PPV), stroke volume, stroke volume variation (SVV), systemic vascular resistance (SVR), global end-diastolic volume, intrathoracic blood volume, and extravascular lung water during hypothermia and rewarming. - Changes in parameters of cardiac compliance during hypothermia and rewarming. - Changes in cerebral, renal and splanchnic blood flow during hypothermia and rewarming. - Changes in cerebral autoregulation during hypothermia and rewarming. - Effect of fluid resuscitation on hemodynamic parameters and whole blood viscosity during hypothermia and rewarming. | — |
Countries
Netherlands
Outcome results
None listed