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Spiral Artery Remodelling (SPAR) in Normal Pregnancy and Pre-eclampsia * Pilot Study

Spiral Artery Remodelling (SPAR) in Normal Pregnancy and Pre-eclampsia * Pilot Study - SPAR study

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON35300
Enrollment
70
Registered
2011-08-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia toxemia of pregnancy

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Women having preeclampsia in need of a caesarean section Women having a intra uterine growth restriction in need of a caesarean section Women having a normal pregnancy in need of a caesarean section

Exclusion criteria

Exclusion criteria: In case of operative complications in terms of, for example, excessive blood loss the surgeon in charge may decide that there is no time to perform the placental biopsies

Design outcomes

Primary

MeasureTime frame
Vascular lesions will be scored according to a systematic pathologic classification system; additional metabolic and immunological profiling of plasma and placental samples will be performed to investigate the link between maternal cardiovascular risks factors and vascular lesions of the placental bed due to defective spiral artery remodelling. The latter will be obtained through the SMART collaborative—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)