Effects of N-3 fatty acids (DHA and EPA) on cognitive control and associated brain activity in ADHD: A double-blind placebo controlled study

Effects of N-3 fatty acids (DHA and EPA) on cognitive control and associated brain activity in ADHD: A double-blind placebo controlled study - N-3 fatty acids in ADHD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35299

Enrollment

Registered

2008-11-11

Start date

2009-01-23

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD attention deficit

Interventions

The intervention group will receive 10 grams of margarine enriched with n-3 daily for 16 weeks. The placebo group will receive a similar product, without the n-3 enrichment.

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: General: 1) 8-14 year old boys 2) Used to daily consumption of margarine 3) Sufficient mastery of the Dutch language of both the subject and his parents ADHD-group: 1)DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview 2) Scores in the clinical range on the Child Behaviour Checklist (CBCL) and Teacher Rating Form(TRF)

Exclusion criteria

Exclusion criteria: 1) mental retardation (IQ

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is changes in MR signal with n-3 supplementation.	—

Secondary

Measure	Time frame
The secondary outcome measures are changes with n-3 supplementation in: 1) cognitive control (Accuracy and RT on the go/no-go task) 2) ADHD symptoms 3) fatty acid status assessed in cheek cells 4) dopamine metabolites assessed in urine	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)