high blood pressure hypertension
Conditions
Interventions
The hypertensive subjects will be asked to discontinu the intake of
antihypertensive medication 3 weeks prior to the study.
All subjects will be asked to collect urine during 24hrs prior to the firs
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria healthy normotensive subjects : 18-60 years, Caucasian, blood pressure 140/90mmHg.
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy normotensive and hypertensive subjects: Obesity (BMI>27kg/m2), cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure), diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), pregnancy, and wearing contact lenses.;Exclusion criteria for normotensive obese subjects: cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure), impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), pregnancy, and wearing contact lenses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - functional recruitment of capillaries in the skin. | — |
Secondary
| Measure | Time frame |
|---|---|
| - perfused capillary density in the nailfold. - Endothelium- (in)dependent vasodilatation of finger skin microcirculation - Density of arterioloes, capillaries and venules in the bulbar conjunctiva. - Diameter of arterioles and venules in the bulbar conjunctiva. - Insulin sensitivity | — |
Countries
Netherlands
Outcome results
None listed