hypoxic-ischaemic encephalopathy oxygen depreviation perinatal asphyxia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Gestational age of at least 37 weeks and two of the following criteria: - Signs of fetal distress: late decelerations or decreased variability of fetal heart rate on cardiotocography, or meconium stained amnion fluid, or fetal scalp blood ph 5 minutes - Multi-organ failure
Exclusion criteria
Exclusion criteria: - Congenital malformations - Documented chromosomal abnormalities - Inherited errors of metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of concentrations of oxidative stress parameters (NPBI, 8-isoprostane) and neuro-biomarkers (S100B, NSE and B-FABP) in cord blood, arterial blood at 0-6, 72, 108 hours and in saliva and urine at 0-6, 8, 12, 16, 20, 24, 36, 48, 72, 96 en 108 hours after birth. Outcome measurements for hypoxic ischemic brain injury are brain injury on MRI (day 3-5) or neonatal mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome measurements for adverse long-term outcome are neurodevelopmental abnormalities at 18 months and 5 years of follow-up. | — |
Countries
Netherlands
Outcome results
None listed