parodontitis RA risk group or pre-RA group
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients who are ACPA and or RF positive and who have arthralgia*s, aged > 18 years.
Exclusion criteria
Exclusion criteria: Fullfilling ACR criteria for RA. Exclusion criteria (according to the SENIEUR protocol 1984) 1. Infection other than periodontitis. 2. Inflammation other than periodontitis (RA, Crohn*s disease, collagen-vascular diseases). 3. Malignancy, past or present. 4. Other conditions which influence the immune system: diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication 10mg/day, antibiotic use during 3 months prior to the study. 9. Periodontal treatment prior to the study. 10. Edentulism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical parameters: Disease Activity Score 28 joint count (DAS28 and DAS44) Periodontitis: Periodontal Inflamed Surface Area (PISA (Nesse et al. 2008) and extent of alveolar bone loss measured on an panoramic radiograph. Biomarkers: ACPA titer and anti-Pg titer | — |
Secondary
| Measure | Time frame |
|---|---|
| Leukocyte count, CRP and ESR. Presence of citrullinated proteins, ACPA and expression of PAD-2 and -4 enzymes in GCF, SF and tissue, cell types present in tissue. Presence of P. gingivalis in subgingival plaque. Presence of HLA-DRB1* shared epitope (SE) alleles. Lymphocyte subsets with an emphasis on CD161 staining | — |
Countries
Netherlands
Outcome results
None listed