Pilot-study: Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia; Relation to sleep

Pilot-study: Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia; Relation to sleep - Effect of dexamethasone on sleep after childhood ALL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35272

Enrollment

150

Registered

2009-03-24

Start date

2010-03-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

leukemia sleepproblems

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: - all children that have been treated according to the ALL-9 (VUmc) or ALL-10 (VUmc, WKZ, UMCN) protocol because of acute lymphoblastic leukemie - fluent in Dutch

Exclusion criteria

Exclusion criteria: - Down syndrome - Long-term use of corticosteroids for other reasons than ALL - other chronic or serious conditions, influencing sleep and/or behavior

Design outcomes

Primary

Measure	Time frame
Function of the HPA axis will be evaluated with the use of salivatory cortisol and a low-dose dexamethasone suppression test. Information on sleep, fatigue and quality of life will be gathered through questionnaires.	—

Countries

Netherlands

Outcome results