Insulin insensitivity Insulin resistance
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1- Lean and obese (body mass index > 20 kg/m2) subjects undergoing elective surgery 2- Age 18 - 60 years 3- Normal liver and renal function tests 4- Informed consent
Exclusion criteria
Exclusion criteria: 1- Surgery for malignant or active inflammatory conditions 2- Treated diabetes 3- Any medication interfering with insulin sensitivity (steroids, beta-blockers) 4- HbA1c >8% 5- Intensive sports (> three times weekly) 6- Malignant disease 7- Infectious disease (raised erythrocyte sedimentation rate or C-reactive protein) 8- Any medical disorder of significant relevance 9- DM II in first degree family members 10- Hypertriglyceridemia or any other lipid metabolism disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Acylcarnitine profiles in human plasma and muscle, liver and fatty tissue - The correlation between these acylcarnitine profiles and insulin sensitivity and resting energy expenditure in each individual patient | — |
Countries
Netherlands
Outcome results
None listed