coronary artery disease coronary atherosclerosis
Conditions
Interventions
nvt
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Cases: men with coronair artery disease under the age of 51 years and a positive family history of premature CVD. Controls: matched for sex, age and smoking habits
Exclusion criteria
Exclusion criteria: Cases: no cardiovascular event below 51 years Controles: history or complaints of cardiovascular disease, positive family history of cardiovascular disease, use of medication. Additional exclusion criteria because of carbasaalcalcium and statin administration: - Allergy for carbasalaatcalcium or simvastatin. - Liver function disorders defined as the upper normal limit of ALAT and ASAT - CPK above three time upper normal limit - Renal impairement Additional exclusion criteria for carbasalaatcalcium use: - Gastric pain or complaints with former use - Gastric bleeding or perforations - Ulcers in stomach, esophagus or bowels - Hypoprothrombinemia Additional exclusion criteria for statin use: - Consumption of excessive amount of alcohol defined as 21 units/week - Hypothyoidism - Familiar muscle disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MiRNA expression patterns of thrombocytes, monocytes, plasma and endothelial cells. | — |
Secondary
| Measure | Time frame |
|---|---|
| nvt | — |
Countries
Netherlands
Outcome results
None listed