Validation of a new protocol for the methacholine provocationtest in patients with hyper-reactive airways.

Validation of a new protocol for the methacholine provocationtest in patients with hyper-reactive airways. - METHA2-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35238

Enrollment

Registered

2010-06-07

Start date

2010-06-08

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

airway hyper-responsiveness increased sensitivity of the airways

Interventions

Participating subjects will perform two times a bronchial provocation test (BPT). Subjects will be randomly divided into two groups. Group one will measure first with the DeVilbiss 646 jet nebulizer

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >= 18 years. Symptoms off bronchial hyper-reactivity. Positive provocation test (PD20).

Exclusion criteria

Exclusion criteria: Recent use of oral or inhaled bronchodilators Severe airways obstruction at baseline (FEV1 200 mmHg or diastolic pressure > 100 mmHg Pregnancy Epilepsia dependent on medication

Design outcomes

Primary

Measure	Time frame
The severity of AHR can be expressed in de amount of metacholine dosage in miligram that causes a 20% fall in FEV1, known as the PD20.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)