Inflammatoire biomarkers, zoals cytokinen, chemotaxie en concentratie nutrienten (lycopeen, vitamine C en alpha-tocopherol) in humaan bloed Inflammation
Conditions
Interventions
3 Day Run-in period
During the 3-days-run-in period the subjects are instructed to avoid
consumption of tomatoes and tomato products, seeds and nuts, egg yolk, all
other fruits and vegetables, herbs
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: BMI 20- 30 kg/m2 Age >18 years No reported physical and/or mental disease(s) or major surgery that might limit participation in or completion of the study No reported renal and/or cardiovascular disorder(s)/disease(s) No reported metabolic disorders/diseases in particular no diabetes mellitus type 1 and 2 No use of any medication that is known to influence lipid and glucose metabolism as well as blood pressure from at least one month before beginning of the study until the end of it
Exclusion criteria
Exclusion criteria: Use of any medication (1 month prior to the start of the study and during the study) Consumption of 3 or more glasses of alcoholic drinks per day Donation of more than 500 ml blood (
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The secundairy parameters are: a. Chemotaxis of monocytes ex-vivo exposed to plasma. b. Plasma concentrations of lycopene and its stereoisomer, a-tocopherol and ascorbic acid. | — |
Primary
| Measure | Time frame |
|---|---|
| The study parameters are: a. The release of the cytokines TNF-a, IL-8 and IL-10 from blood upon ex-vivo stimulation with LPS. | — |
Countries
Netherlands
Outcome results
None listed