The Dutch famine birth cohort study: consequences of a suboptimal start in life

The Dutch famine birth cohort study: consequences of a suboptimal start in life - Dutch famine birth cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35232

Enrollment

500

Registered

2011-12-09

Start date

2012-11-02

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

veroudering incl cognitieve achteruitgang ageing

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: men and women born as term singletons around the time of the Dutch famine in the Wilhelmina Gasthuis, Amsterdan, the Netherlands, between 1 november 1943 and 28 february 1947

Exclusion criteria

Exclusion criteria: na

Design outcomes

Primary

Measure	Time frame
- cognitive decline - incidence of white matter hyperintensities and cerebral microbleeds - cerebrovascular function - endothelial function - incidence of stroke - incidence of fractures - grip strength and physical performance - visual acuity - incidence of cataract operations - hearing - mortality.	—

Secondary

Measure	Time frame
cerebrovascular function - cellular ageing (quantified by telomere length) - oxidative stress (quantified by a comet assay) basal inflammation (quantified by the inflammatory factors C-reactive protein (CRP) and total leukocyte count).	—

Countries

Netherlands

Outcome results