depression major depressive disorder
Conditions
Interventions
rTMS on the right parietal cortex
2 Hz with an inter-impuls interval of 0,5 sec.
at 110 % of motor threshold
15 sessions of 20 minutes during a period of three weeks
Sponsors
Sint Lucas Andreas Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age from 18 yrs onward unipolar depressive disorder only the following medication is allowed: SSRI's, venlafaxine, mirtazapine, antihistamanics for sedation medication to be kept constant during the trial
Exclusion criteria
Exclusion criteria: bipolar disorder, dysthymic disorder suicidality Use of beta-blockers, other antidepressants or psychotropic medication, thyroid hormone, benzodiazepines, anti-epileptics history of epilepsy or epileptic abnormalities on EEG intracranial metal, pacemaker schizophrenia, addiction, mental handicap, not speaking Dutch lefthandedness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Percentage of change from baseline on the Hamilton Depression Rating Scale (HAMD, 17 items) 2. Percentage of patients with clinical response (= 50 % reduction in HAMD score) 3. Percentage of patients with partial clinical response (= 30 % reduction in HAMD score) | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotion Recognition Task | — |
Countries
Netherlands
Outcome results
None listed