epilepsy fits seizures
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: 1. A total of 30 to 50 children, younger than 17 years of age, with new onset partial epilepsy -who may present with generalized seizures. 2. A total of 30 to 50 children, younger than 17 years of age who were judged, after taking the clinical history and recording of a standard EEG, not to have had seizures (also excluding children with febrile convulsions)
Exclusion criteria
Exclusion criteria: Patients > 16 years of age. Children with idiopathic generalized epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the cause of change in seizures semiology Analyses will be performed of associations between changes in seizure semiology and changes in the development of neuronal networks and: 1 changes in underlying brain pathology 2 remote damage (e.g. dual pathology/ mesial temporal sclerosis) 3 the pattern of epileptiform activity during seizure onset, or speed of seizure spreading Assessment of differences in neuronal networks in children with and without epilepsy 1 What are the baseline differences in neuronal networks in children with new onset partial epilepsy and children without seizures. 2 What are the differences in neuronal networks in children with partial epilepsy compared to the group of children without seizures three years after the diagnosis of epilepsy or first assessment in the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| How often do we see a change in seizure semiology in children 1 How does seizure semiology change? (a definition of change in semiology is described in the work plan). 2 What are the clinical characteristics of the children in whom seizure semiology changes? (Characteristics that are examined are described in the work plan) 3 What is the time course of changing semiology? | — |
Countries
Netherlands
Outcome results
None listed