The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls.

The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls. - Relation between serotonin levels and genotype of serotonin transporters

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35209

Enrollment

105

Registered

2009-11-05

Start date

2011-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carcinoid tumoren Carcinoid tumors depression mood disorder serotonin producing tumors

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers Patients with serotonin producing carcinoid tumors Patients on SSRIs for the treatment of depression

Exclusion criteria

Exclusion criteria: Subjects on mediation that influences serotonin-metabolisme, such as aspirine, antidepressive medication, MAO-inhibitors or is involved in serotonin reuptake, with the exception of SSRIs in the SSRI group.

Design outcomes

Primary

Measure	Time frame
Free and stored serotonin and dopamine is measured in plasma and trombocytes, respectively. DNA is isolated form whole blood for genotyping of the serotonine transporter.	—

Countries

Netherlands

Outcome results