Cerebrovascular disease stroke
Conditions
Interventions
All volunteers and patients will be exposed to step wise respiratory challenges
with a maximum of 4 minutes of end tidal CO2 pressure (= arterial pressure) of
50 mmHg CO2 and minimum O2 level of 100
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (p. 15 protocol) > 18 year informed consent Intracranial occlusion Extracranial occlusion Extracranial stenosis In stroke patients, MRI scan within one week of symptom onset
Exclusion criteria
Exclusion criteria: (p.15 protocol) Contraindications for MRI (claustrophobia, or standard MRI contraindications such as pacemakers or specific metal objects in or around the body) Unwilling or unable to co-operate with breathing manoeuvres Respiratory or cardiac limitations to breathing at 20L/min Medical contra-indications to limited hypercapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis) Altered consciousness Non compliance with prescribed anti-seizure medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our objective is to test the feasibility of the application of a CO2-challenge to measure Cerebrovascular Reactivity in healthy subjects and in cerebrovascular diseased patients with Arterial Spin Labeling MRI and to test the feasibility of a Velocity-Selective Spin Labeling sequence to measure the Cerebral Metabolic Rate of Oxygen. | — |
Secondary
| Measure | Time frame |
|---|---|
| To obtain baseline values of these two parameters in a healthy control group and in patients with cerebrovascular disease. | — |
Countries
Netherlands
Outcome results
None listed