headache Migraine
Conditions
Interventions
None listed
Sponsors
Neurologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Migraineurs Inclusion criteria; i) Female migraine patients, suffering from menstrually related migraine according to IHS criteria; ii) in total, 1-2 attacks of migraine per month; iii) aged between 18-50 years; iv) provided written informed consent; v) preferable, no use of acute anti migraine medication during the study* and vi) a regular menstrual cyclus.;Healthy controls Inclusion criteria; i) Having a regular menstrual cycle; ii) aged between 18-50 years; iii) provided written informed consent;
Exclusion criteria
Exclusion criteria: Migraineurs Exclusion criteria: i) other neurological or psychiatric disease; ii) contraindications for being in a MR-scanner; iii) use of medications that may influence brain functioning (antidepressants; sedatives); iv) use of prophylactic antimigaine medication; v) presence of premenstrual syndrome; vi) having undergone procedures that influence regularity of menstrual cyclus, such as ovariectomy and hysterectomy; and vii) use of (oral) contraceptives.;Healthy controls Exclusion criteria: i) any neurological or psychiatric disease, including primary headache syndrome; ii) headache prior to menstrual flow; iii) contraindications for being in a MR-scanner; iv) use of medications that may influence brain functioning (antidepressants; sedatives); v) symptoms of premenstrual syndrome; vi) having undergone procedures that influence regularity of menstrual cyclus, such as ovariectomy and hysterectomy; vii) using medication that is also prescribed for migraine prophylaxis (ß-blokkers etc.), and viii) use of (oral) contraceptives.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome parameters: - MR: RSN measurements: Time-dependent changes in neuronal activity as reflected by the BOLD signal in several functional networks; Time-dependent changes in regions; (voxel-wise) functional connectivity. - Cognitive tests: results of global-local task - Venapuncture: levels of female hormones (LH, FSH, oestrogen) - Questionnaires: information on presence/ absence of premonitory symptoms and headache | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed