onderzoek bij gezonde vrijwilligers n.v.t
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Males: Healthy, right-handed, non-smoking volunteers, aged between 18-35 years ; Females: Healthy, right-handed, non-smoking, aged between 18-35 years, using contraceptives
Exclusion criteria
Exclusion criteria: Metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history of epilepsy, history of closed-head injury, history of head surgery, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), brain infarction, pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortico-cortical networks will be reconstructed by computing the level of statistical dependency between the electrode signals across different frequency bandwidths (1-30Hz), by means of computing the level of coherence between the time-series of the different electrodes. From the resulting individual cortico-cortical networks, graph metrics that describe the topology of the network will be computed, with the mean focus on the level of degree -number of connections in the network-, local efficiency -expressing the level of local clustering of nodes- and global efficiency -computed as the inverse of the minimal number of steps to travel between any two nodes, expressing how efficient information can be transported between different parts of the network. Next, network stability will be assessed by determining the test-retest reliability of these metrics across the different time-points for the different frequency bandwidths across the group of subjects. | — |
Countries
Netherlands
Outcome results
None listed