Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children

Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children - MymIC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35170

Enrollment

1000

Registered

2008-05-06

Start date

2008-06-25

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

common cold Respiratory tract infection

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Group A · Age: ³3 months and

Exclusion criteria

Exclusion criteria: Severe concomitant disease (chronic lung disease, neoplasia, liver or kidney disease, immunodeficiency, cardiovascular disease, psychomotor impairment). Nosocomial infection. Use of antibiotics in the 48 hours that preceded enrollment or azithromycin within 1 week before enrollment

Design outcomes

Primary

Measure	Time frame
In this explorative study, M. pneumoniae will be quantified in nose- and throat swabs/aspirates of children aged 0-16 years with mild to severe symptoms of respiratory tract infection, and in a control group consisting of children without respiratory tract infection. The quantity of M. pneumoniae (in copies/ml or copies/swab) will be related to clinical disease in order to differentiate asymptomatic carriership from infection. To investigate the role of co-colonization or -infection, the presence of other bacteria or viruses in the respiratory tract will be analyzed as well. To study the age distribution in relation to M. pneumoniae infection, a precalculated number of patients of either = 5 years of age will be included. Genotyping of M. pneumoniae will be performed, and related to severity of disease and/or colonization. Prevalence of colonization and/or infection with M. pneumoniae will be calculated.	—

Measure

Time frame

In this explorative study, M. pneumoniae will be quantified in nose- and throat swabs/aspirates of children aged 0-16 years with mild to severe symptoms of respiratory tract infection, and in a control group consisting of children without respiratory tract infection. The quantity of M. pneumoniae (in copies/ml or copies/swab) will be related to clinical disease in order to differentiate asymptomatic carriership from infection. To investigate the role of co-colonization or -infection, the presence of other bacteria or viruses in the respiratory tract will be analyzed as well. To study the age distribution in relation to M. pneumoniae infection, a precalculated number of patients of either = 5 years of age will be included. Genotyping of M. pneumoniae will be performed, and related to severity of disease and/or colonization. Prevalence of colonization and/or infection with M. pneumoniae will be calculated.

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Countries

Netherlands

Outcome results