The effect of Remote Ischemic Preconditioning on plasma troponin I appearance after a standardized cycling test in healthy volunteers

The effect of Remote Ischemic Preconditioning on plasma troponin I appearance after a standardized cycling test in healthy volunteers - Exercise test and cardiac injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35150

Enrollment

Registered

2011-08-16

Start date

2011-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac injury

Interventions

Maximal bicycle test (to determine maximal heart rate), at least one week later followed by two intensive bicycle exercise tests per volunteer, separated by at least 2 weeks. One of these intensive

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Age : 18-45 years • Willing to sign informed consent • Healthy

Exclusion criteria

Exclusion criteria: • Hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg) • Any cardiovascular abnormality in past medical history, physical examination or ECG, including prolonged QTc interval. • Drug abuse • Alcohol abuse (> 3 units/day) • Smoking during the last 2 years • BMI>=30 kg/m2 • Inability to perform bicycle exercise • The presence of an absolute or relative contra-indication for exercise testing (table 2) • The presence of diabetes (fasting glucose > 6.9 mmol/l, non-fasting glucose > 11.0 mmol/l; if non-fasting glucose is > 6.9 mmol/l, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/l.) • Total cholesterol in blood 6.5 mmol/l or higher

Design outcomes

Primary

Measure	Time frame
Serum levels of hs-troponin I in response to intensive exercise test.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)