The genetic basis of meningococcal and other life threatening bacterial infections of childhood

The genetic basis of meningococcal and other life threatening bacterial infections of childhood - EUCLIDS (EU Childhood Life-threatening Infectious Diseases Genetics Study)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35124

Enrollment

600

Registered

2012-07-30

Start date

2012-11-14

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

meningitis sepsis

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Patients aged 1 month-18 years with a clinical syndrome indicating severe invasive bacterial disease such as septicaemia, toxic shock syndrome, empyema, meningitis, osteomyelitis and septic arthritis, will be eligible for recruitment into the study, anytime they fulfil any of the definitions established for each eligible condition zie EUCLIDS project CLINICAL PROTOCOL Version 3.0. - 10/AUG/2011 p 10-14

Exclusion criteria

Exclusion criteria: Sepsis by other pathogens. Patients with immunodeficiency.

Design outcomes

Primary

Measure	Time frame
We will validate the gene variants identified in the MD GWAS for their role in susceptibility and severity using the cohorts of patients with staphylococcal infection, pneumococcal infection, and Group A streptococcal infection. The relation between Gene variants and etiologic agent, severity and outcome will be analysed.	—

Countries

Netherlands

Outcome results