ADHD Attention-Deficit/Hyperactivity Disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Diagnosed with ADHD (DSM-IV criteria) * History of mild cannabis use for at least one year (less than once/wek and more than 4 times / year) * Right-handedness, assessed with the Edinburgh Handedness Inventory * Written informed consent of the participant
Exclusion criteria
Exclusion criteria: * Any clinical significant abnormality of any clinical laboratory test, except for the predetermined psychiatric disorder, i.e. ADHD, including urinary screening * Impaired physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests (see par 8.3.1.) * history of alcohol and /or drug abuse (DSM-IV criteria) * Body Mass Index (B.M.I) 28 kg/m2 * any subject who received any investigational medication within 90 days prior to the start of the study or who is scheduled to receive an investigational drug * use of any medication within three weeks prior to the start of the study, except for paracetamol and medication for ADHD and related symptoms * contra-indications for MRI (claustrophobia, metal objects in body (e.g. braces, pacemakers, metal clips)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of the study is the Blood-Oxygenation-Level-Dependent (BOLD)-signal, measured with fMRI | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral parameters (reaction time, accuracy) during performance of the tasks in the scanner and during performance of the neuropsychological tests. Melatonin levels in saliva Bloodplasma levels of THC and its main metabolites | — |
Countries
Netherlands
Outcome results
None listed