Febrile convulsions Febrile seizures
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Patient suffers from complex febrile seizures and is between 3 and 10 years of age. Control patients does not suffer from febrile seizures and is between 3 to 10 years of age.
Exclusion criteria
Exclusion criteria: If the patients suffer from another type of epilepsy If they use antiepileptic medication Less then three generations Dutch ancestors Within 24h before the blood collection suffering from a FS or fever Other neurological or metabolic disorders or general health problems Control patient suffer from febrile seizures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRNA and protein levels of FS1 will be measured, The mean level in the patient group will be compared with a control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| The FS1 gene will be sequenced in patients and controls, to possibly find the mutation that is responsible for the expression change. Possible other genes in the FS1 pathway will be investigated | — |
Countries
Netherlands
Outcome results
None listed