Muscle relaxation time as outcome measure for myotonia in patients with non-dystrophic myotonic syndromes (NDMs)

Muscle relaxation time as outcome measure for myotonia in patients with non-dystrophic myotonic syndromes (NDMs) - Muscle relaxation time measurements in NDMs patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35097

Enrollment

Registered

2010-04-06

Start date

2010-04-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inherited skeletal muscle stifness non-dystrophic myotonic syndromes (NDMs)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with a genetically confirmed mutation in the gene encoding the skeletal muscle sodium channel (SCNA4) or skeletal muscle chloride channel (CLCN1) and healthy volunteers (18-65 years old).

Exclusion criteria

Exclusion criteria: Neurological or metabolic comorbidity which affect the muscles. The use of medication which affect myotonia or muscle strength (mainly sodium chanel blockers). Presence of renal or cardiac diseases that do not allow the participant to follow a potassium restricted diet. For the same reason, pregnant woman are not allowed to participate in this study.

Design outcomes

Primary

Measure	Time frame
Average muscle relaxation time (RT) of the right underarm flexors measured by - (1) handgrip myometry - (2) muscle- elastography (measured with echography)	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results