Parkinson's
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: PD patients must fulfill the United Kingdom Parkinson*s Disease Society Brain Bank criteria for idiopathic PD. PD patients must be allocated to subtype 4 based on their clinical scores. A minimum age of 18 years is required for both patients and control subjects.
Exclusion criteria
Exclusion criteria: Control subjects with a disease of the central nervous system. Participants with a contraindication for MRI.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Primary
| Measure | Time frame |
|---|---|
| The main study parameters of this study will include clinical and magnetic resonance imaging (MRI) parameters. Clinical data include important demographic and disease-related characteristics as well as measures for disease severity, and the important motor (motor functioning and motor complications) and non-motor domains (cognition, depression, psychotic symptoms, depression, sleep problems, and autonomic dysfunction). The combination of clinical scores allocates patients in one of the four subtypes, and in this study, only patients allocated in the most severe PD subtype 4 are participating. The MRI measures will include volumetric, diffusion, and functional MRI. | — |
Countries
Netherlands
Outcome results
None listed