brain lesion malformation of cortical development
Conditions
Interventions
None listed
Sponsors
Epilepsiecentrum Kempenhaeghe
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: Legally capable adults with and the diagnosis of localization-related seizures and a BOSD on a state-of-the art 3 Tesla MRI. Based on the seizure semiology and EEG the BOSD must be most likely epileptogenic focus. In our files we have over 50 patients who fulfil the inclusion criteria for this study. Normal volunteers: Legally capable adult volunteers without a serious medical problem and no medical history of head trauma or other neurological or psychiatric diseases.
Exclusion criteria
Exclusion criteria: Contra indications for MRI For the normal volunteers: medical history of head trauma or other neurological or psychiatric disease the expressed wish not to be informed whenever structural abnormalities are found during imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For DTI the quantitative outcome parameters will be the local apparent diffusion coefficient (ADC), fractional anisotropy (FA), and tract volume and tract FA values seeded in the white matter region close to the BOSD. These parameters will be obtained in the region close to the BOSD and the corresponding contralateral (normal) regions. For rs-fMRI the correlation coefficient will be determined between the rs-fMRI time course signal from a region in the BOSD and all voxels in the rest of the brain. The resulting map will be compared with the same analysis seeded to the contralateral region. Besides the time courses, also the spectrum (Fourier transformed signal) of the time courses will be analyzed. For this the amplitudes of the spectral components in the high (> 80 mHz) and low ( | — |
Secondary
| Measure | Time frame |
|---|---|
| Normal volunteers will be scanned twice to access the inter-scan variability of the connectivity parameters. | — |
Countries
Netherlands
Outcome results
None listed