Humoral and cellular immune response after influenza vaccination in patients with postcancer fatigue and in patients with the chronic fatigue syndrome.

Humoral and cellular immune response after influenza vaccination in patients with postcancer fatigue and in patients with the chronic fatigue syndrome. - Influenza study PCF and CFS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35062

Enrollment

Registered

2010-08-20

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronisch vermoeidheidssyndroom Fatigue tiredness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: No indication for influenza vaccination

Exclusion criteria

Exclusion criteria: An immune deficiency or an chicken protein allergy

Design outcomes

Primary

Measure	Time frame
With every blood collection, hemoglobin level, trombocytes, and the amount and differentiation of leukocytes will be checked. This assessment will take place in the UMC St. Radboud in Nijmegen. The remaining blood will be analyzed by the TIL (Tumor Immunologisch Laboratorium, associated with the UMC St. Radboud) and by the department of Virology of the UMC St. Radboud in Nijmegen. This analysis will concern the actual immune response to the vaccin. Humoral (antibodies) and cellular (T-cell mediated) reactions to the influenza vaccin will be measured. The first time blood will be collected, an additional 20 ml of blood will be collected (2,5 ml for BSE, 3 ml for alkaline phosphatase, ALAT, creatine kinase, sodium, potassium, calcium, UK, CRP and iron, 3 ml for bicarbonate, 3 ml for ferritin, 2 ml for glucose, 3.5 ml for TSH and T4V and 3 ml for albumin) to screen for possible alterations in the blood, which could explain the fatigue complaints, like anemia or hyperthyreoidie.	—

Measure

Time frame

With every blood collection, hemoglobin level, trombocytes, and the amount and differentiation of leukocytes will be checked. This assessment will take place in the UMC St. Radboud in Nijmegen. The remaining blood will be analyzed by the TIL (Tumor Immunologisch Laboratorium, associated with the UMC St. Radboud) and by the department of Virology of the UMC St. Radboud in Nijmegen. This analysis will concern the actual immune response to the vaccin. Humoral (antibodies) and cellular (T-cell mediated) reactions to the influenza vaccin will be measured. The first time blood will be collected, an additional 20 ml of blood will be collected (2,5 ml for BSE, 3 ml for alkaline phosphatase, ALAT, creatine kinase, sodium, potassium, calcium, UK, CRP and iron, 3 ml for bicarbonate, 3 ml for ferritin, 2 ml for glucose, 3.5 ml for TSH and T4V and 3 ml for albumin) to screen for possible alterations in the blood, which could explain the fatigue complaints, like anemia or hyperthyreoidie.

—

Secondary

Measure	Time frame
N.v.t.	—

Countries

Netherlands

Outcome results