heartfailure
Conditions
Interventions
1. moderate-intensity training (traditional training) for 12 weeks (3 times per
week)
2. high-intensity training for 12 weeks (3 times per week)
3. control
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - heart failure class II or III (diagnosed according to the NYHA-classification) - patients must be in a stable situation (*3 month) using the same medication
Exclusion criteria
Exclusion criteria: - smokers - diabetes (type I and II) - mild renal impairment or proteinuria - hepatic impairment - hypercholesterolaemia - exercise-induced ischaemia - hypertension (grade II; >160 systolic blood pressure or >100 diastolic blood pressure) - atrial fibrillation - pre-menopausal females or those on hormone replacement therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -physical fitness (maximal cycling test) -NO-mediated endothelial function of the brachial artery (flow-mediated dilation) -NO-mediated endothelium-dependent and -independent dilation of the forearm resistance arteries -contribution of endothelin to the baseline forearm resistance artery vascular tone | — |
Secondary
| Measure | Time frame |
|---|---|
| -cardiac function and structure (echocardiography) -bloodparameters which have a (in)direct relation with the progression and severity of heart failure (e.g. endothelin, cholesterol, LDL, HDL, triglycerides, hs-CRP, fibrinogen, homocysteine, N-terminal pro-brain natriuretic protein) | — |
Countries
Netherlands
Outcome results
None listed