The CPB; fibrinoLysis Or Thrombosis? (CLOT) study, understanding the effects of CPB on coagulation and fibrinolysis to improve treatment of blood loss after cardiac surgery.

The CPB; fibrinoLysis Or Thrombosis? (CLOT) study, understanding the effects of CPB on coagulation and fibrinolysis to improve treatment of blood loss after cardiac surgery. - CLOT study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35050

Enrollment

Registered

2010-06-16

Start date

2010-07-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coagulation disturbance Coagulopathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Coronary artery bypass graft (CABG), isolated and combined with aortic valve replacement (AVR) * Left ventricle ejection fraction > 35% * Age >18 years

Exclusion criteria

Exclusion criteria: * Any other procedure than CABG whether or not combined with AVR * Emergency surgery * History of bleeding diathesis or coagulopathy * Participation in any study involving an investigational drug or device * Inability to understand the study information and/or sign informed consent

Design outcomes

Primary

Measure	Time frame
Several parameters will be studied in the collected blood samples, e.g.: Coagulation: - Aggregometer --> platelet aggregation - Prothrombin time, Activated partial thromboplastin time, fibrinogen, D-dimer - Platelets Fibrinolysis: Fibrinolytic assays (t-PA activity, PAI-I activity etc.) Thromboelastography, Fluorescence Activated Cell Sorter	—

Secondary

Measure	Time frame
Peroperative: - Operation time - CPB time - Aortic clamping time Postoperative: - Bloedtransfusions within 48 hours after surgery - Amount of blood loss within 48 hours after surgery - Total amount of blood loss after surgery	—

Countries

Netherlands

Outcome results