Kinetics of IroN in Donors

Kinetics of IroN in Donors - KIND

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35042

Enrollment

Registered

2010-12-07

Start date

2011-11-08

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fysiologisch herstel na bloeddonatie in gezonde mannen Iron status after blood donation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male, Donor since max 2 years, BMI between 20 and 27, length at least 175 cm, age between 30 and 60, ferritin at start between 120 and 250 microgram per litre, ALAT and CRP normal at start

Exclusion criteria

Exclusion criteria: vegetarian, blood type O neg

Design outcomes

Primary

Measure	Time frame
Blood will be drawn 11 times in 8 weeks. DNA will be isolated and stored, and iron parameters measured. Furthermore, the participants will be asked to complete a shortened food frequency questionnaire specifically aimed at measuring iron intake, developed by the university of Wageningen. The iron parameters included in this study are: Hemoglobin (Hb) Mean Corpuscular Volume (MCV) soluble transferrin receptor (sTR) Hepcidin Iron Transferrin Reticulocytes and Reticulocyte Hb Ferritin C-Reactive Protein (CRP) Zinc ProtoPorfyrin (ZPP) Samples will be taken pre-donation, on the day of donation at 1, 2, 4 and 8 hours after donation and on days 2, 4, 8, 15, 29, 57 after donation. Not all parameters will be measured at all times. The timing of specific measurements can be found in the protocol.	—

Measure

Time frame

Blood will be drawn 11 times in 8 weeks. DNA will be isolated and stored, and iron parameters measured. Furthermore, the participants will be asked to complete a shortened food frequency questionnaire specifically aimed at measuring iron intake, developed by the university of Wageningen. The iron parameters included in this study are: Hemoglobin (Hb) Mean Corpuscular Volume (MCV) soluble transferrin receptor (sTR) Hepcidin Iron Transferrin Reticulocytes and Reticulocyte Hb Ferritin C-Reactive Protein (CRP) Zinc ProtoPorfyrin (ZPP) Samples will be taken pre-donation, on the day of donation at 1, 2, 4 and 8 hours after donation and on days 2, 4, 8, 15, 29, 57 after donation. Not all parameters will be measured at all times. The timing of specific measurements can be found in the protocol.

—

Secondary

Measure	Time frame
None	—

Countries

Netherlands

Outcome results