Exhaled Breath profiling by an Electronic Nose in the Diagnosis of Pulmonary Sarcoidose

Exhaled Breath profiling by an Electronic Nose in the Diagnosis of Pulmonary Sarcoidose - eNose and Pulmonary Sarcoidosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35021

Enrollment

120

Registered

2010-09-17

Start date

2010-04-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung sarcoidosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Adult patients, between 18-70 years old, with a confirmed diagnosis of sarcoidosis. (Diagnosis of sarcoidosis according to the generally accepted consensus criteria.) * Treatment naïve patients. A low dose oral prednisolone (

Exclusion criteria

Exclusion criteria: * Patients with underlying conditions with an established effect on the exhaled VOCs. * Any other respiratory disease except sarcoidosis and/or any systemic diseases. * Respiratory tract infections requiring antibiotics and/or oral steroids in the 4 weeks prior to the study will be excluded. * Current and ex tobacco Smoking. (However, patients with a smoking history of

Design outcomes

Primary

Measure	Time frame
Smellprint of sarcoidosis patients versus controls. Smellprint of patients with different radiological stages.	—

Secondary

Measure	Time frame
Hypothesize that an electronic nose can discriminate between different stages of pulmonary sarcoidosis (sub-phenotyping) Finally we aim to characterize VOCs in samples detected by the electronic nose by gas-chromatography and mass-spectrometry	—

Countries

Netherlands

Outcome results