treatment resistant drug dependence untreatable addiction
Conditions
Interventions
The intervention of this study will be Deep Brain Stimulation (DBS) in the
Nucleus Accumbens (NcAcc) in all participants. Deep Brain Stimulation is an
adjustable, reversible, non-destructive interve
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Chronic course of substance use disorder: minimal duration of 5 years of DSM-IV diagnosis heroin and/or cocaine dependence - Being treatment refractory despite treatment programs - Severe dependence: heroin/cocaine use at least 15 days in last month AND poor physical health AND/OR poor mental health AND/OR poor social functioning
Exclusion criteria
Exclusion criteria: - Current major depression, current suicidality, current OCD. - Current psychosis and no history of psychosis - (history of) severe neurological disorders - Contraindication to perform the operation - Contraindication to participate in fMRI and/or SPECT assesment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measurements include subjective craving and illicit drug use. In addition, urinalysis will be performed to validate self-reported drug use. Concerning the imaging experiments the outcome will be assessed by changes in brain activity with fMRI and changes in striatal dopamine D2 binding with SPECT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include social function and quality of life. | — |
Countries
Netherlands
Outcome results
None listed