gastric emptying satiety
Conditions
Interventions
Application of a well- vs non-emulsified fat drink in the stomach or duodenum
or oral ingestion of the drink.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Sex: male and female age: 18-55 years BMI: 18-29kg/m2
Exclusion criteria
Exclusion criteria: Evidence of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/ connective tissue, musculoskeletal, metabolic/nutritional, endocrine, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint The main study parameter is the amount of fatty acids released after an intragastric fat load of well-emulsified fat | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameters are; - Differences in fatty acid release between an intragastric load of non-emulsified vs. well-emulsified fat - Differences in fatty acid release after oral vs. gastric vs. duodenal administration of well-emulsified fat - Colloidal behaviour (droplet size, flocculation, aggregation, coalescence) in the oral, gastric and duodenal compartment - Lipase activity - Gastric emptying, small bowel transit time - Gut hormones: hormones CCK (blood), GLP-1 (blood) ,PYY (blood en saliva), ghrelin (blood and saliva) - Satiety: VAS (visual analogue scale) - Energy intake at a subsequent meal - Gallbladder motility/ emptying | — |
Countries
Netherlands
Outcome results
None listed