Becker Muscular Dystrophy: analysis of diversity in disease severity

Becker Muscular Dystrophy: analysis of diversity in disease severity - Becker Muscular Dystrophy: analysis of diversity in disease severity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35006

Enrollment

Registered

2010-08-06

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Becker muscular dystrophy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. diagnosis of Muscular Dystrophy, defined by: - male gender AND - progressive muscular weakness AND - elevated serum CPK-levels AND - dystrophic characteristics on muscle biopsy OR - reduced amount of dystrophin in muscle biopsy OR - in frame mutation in DMD gene 2. Age over 18 years

Exclusion criteria

Exclusion criteria: Exlusion for MRI - claustrophobia - pacemaker and defibrillators - nerve stimulators - intracranial clips - intraorbital or intraocular metallic fragments - cochlear implants - ferromagnetic implants (eg. thoracic implant for scoliosis) - inability to lie supine during less than 60 minutes

Design outcomes

Primary

Measure	Time frame
1. Disease course, based on data collected from a structured medical history and information from other treating physicians. 2. Biomarkers from blood 3. Strength and Functional Assessment 4. Muscle MRI 5. Muscle biopsy parameters 6. Echocardiography	—

Countries

Netherlands

Outcome results