Atherosclerosis
Conditions
Interventions
Patients with major ischemia in the *treatment with knowledge of MRI results*-
group will undergo PCI according to standard technique. The cardiologist will
insert a sheath into the femoral artery (o
Sponsors
Cardiologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All patients with stable angina pectoris and >=70% stenosis in at least one epicardial coronary artery (proximal or mid segment) can be included. Stable angina pectoris is defined as Canadian Cardiovascular Society [CCS] class I-III or medically stabilized class IV angina. Patients must be able to give informed consent.
Exclusion criteria
Exclusion criteria: General: - Age 200/100mmHg) unresponsive to medical therapy.;Other cardiac pathology: - Atrial fibrillation. - Cardiogenic shock. - Previous myocardial infarction, defined as: (UNL = upper normal limit) a) New Q wave at any time. b) Spontaneous, total CK/CK-MB >= 1.5 x UNL or troponin >= 2 x UNL. - Congestive heart failure NYHA class >=III. - Previous CABG or PCI. - Unstable angina pectoris (persistent CCS class IV despite medical treatment). - Left main (>= 50%) or 3 vessel disease or markedly positive treadmill test during stage 1 of the Bruce protocol. - Ejection fraction 130 kg. ;Contraindication to MRI contrastagent (Gadolinium): - Renal failure (estimated GFR =70% stenosis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameters are a combined endpoint of time to adverse cardiac events defined as: all-cause mortality, myocardial infarction/acute coronary syndrome, hospitalization for unstable angina with negative biomarkers, coronary artery bypass grafting and coronary angioplasty. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary end points are quality of life (Canadian Cardiovascular Society angina class at follow-up); the usage of antianginal drugs, cost-effectiveness and the prognostic value of hs-cTNT. | — |
Countries
Netherlands
Outcome results
None listed