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Myocardial injury and function in mechanically ventilated children with and without lung injury

Myocardial injury and function in mechanically ventilated children with and without lung injury - The heart during mechanical ventilation

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON34967
Enrollment
75
Registered
2011-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myocardial dysfunction Myocardial injury

Interventions

Insertion of central arterial line with option for thermodilution

Sponsors

Universitair Medisch Centrum Groningen
Lead Sponsor

Eligibility

Age
2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Presence of biochemical evidence of myocardial injury (cardiac Troponin T and/or CK-MB and/or NT pro-BNP greater than the upper limit of the reference value) Mechanical ventilation for at least 24 hours Presence of indwelling central venous line Informed consent obtained from parents or legal caretakers

Exclusion criteria

Exclusion criteria: Mechanical ventilation less than 24 hours History of congenital heart disease Surgery for congenital heart disease History of acquired heart disease (i.e. cardiomyopathy, myocarditis)

Design outcomes

Primary

MeasureTime frame
Haemodynamic indices of myocardial dysfunction (cardiac index, global ejection fraction, dPmax).—

Secondary

MeasureTime frame
Need for vaso-active infusions (dopamine, dobutamine, norepinephrine)—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)