In vivo and in vitro sensitivity measurements of the circadian system. Investigating individual differences.

In vivo and in vitro sensitivity measurements of the circadian system. Investigating individual differences. - Sensitivity of the circadian system

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34957

Enrollment

Registered

2010-04-13

Start date

2010-06-19

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circadiane ritme stoornissen (slaapstoornissen), ploegendienst circadian rhythm disorder shift work syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy males between 20 and 30 years and of average chronotype

Exclusion criteria

Exclusion criteria: Symptoms of possible sleep disorder, time zone transmeridian flights (or more) one month prior to taking part in the study, Shift work during the last 3 months, Colour blindness, Visually impaired, Somatic and psychiatric diseases (no indications of depressed mood), History of chronic diseases, Excessive daily amount of caffeinated drinks, Alcohol and drug problems, Regular medication during past 3 months, Smokers, Females.

Design outcomes

Primary

Measure	Time frame
The effects of full spectrum and blue reduced light during a simulated night shift will be investigated for: the degree of melatonin suppression, skin temperature, self ratings of sleepiness, alertness, and performance. A dim light control will be used. The results on melatonin suppression will be compared within each individual for the degree of phase shift in fibroblast peripheral oscillators.	—

Secondary

Measure	Time frame
Prior light history will be analysed as a covariable to explain individual differences in response to light at night.	—

Countries

Netherlands

Outcome results