Kappa-deleting recombination excision circles (KRECs) and somatic hypermutation (SHM) in Down Syndrome B-lymphocytes.

*Kappa-deleting recombination excision circles* (KRECs) and somatic hypermutation (SHM) in Down Syndrome B-lymphocytes. - BKS-Down; blood

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34940

Enrollment

Registered

2010-05-12

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Down syndrome

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Down syndrome, age >7 years

Exclusion criteria

Exclusion criteria: Infectious disease or treated for malignancy

Design outcomes

Primary

Measure	Time frame
Description of the replication history of DS-B-lymphocytes in relation to reference groups. This replication history will be presented in divisions per B-lymphocyte subpopulation. Somatic hypermutation will be presented as the percentage of mutated V3-20-J allels.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results