Dysphagia in Neuromuscular diseases, pathophysiology and treatment implications

Dysphagia in Neuromuscular diseases, pathophysiology and treatment implications - Dysphagia in neuromuscular diseases

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34892

Enrollment

135

Registered

2010-03-19

Start date

2010-07-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle diseases Neuromuscular diseases

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion (group 1 and 2): - Diagnosis DMD (group 1), NMA (group 2) - Chewing and / or swallowing problems (problems with deglutition, choking, coughing, or the feeling of food sticking in the throat);Inclusion (group 3): - Between 5 and 65 years, without health problems which can lead to dysphagia

Exclusion criteria

Exclusion criteria: Exclusion (group 1 and 2) - Totally fed by tube (non oral feeding) - Other pathology than NMD causing chewing or swallowing problems Exclusion (group 3): - Pathology with chewing or swallowing problems

Design outcomes

Primary

Measure	Time frame
Group 1 and 2: - Complaints and symptoms of swallowing problems - Degree of (dys)function of the mandible with objective (mandibular opening in mm, description of craniofacial and dental occlusions) and subjective measures (MFIQ) - sEMG of the submental muscle group during swallowing of thin liquid, semi solid and solid food with different head postures (duration (in sec) and amplitude (in µV )) - Dysphagia limit (in sec) - Maximal tongue pressure (in mmHg) during swallowing of thin liquid, semi solid and solid food - Information of the oral, pharyngeal and esophageal phase of swallowing from the videofluoroscopic swallow study - Echo density of the tongue structure and muscle thickness representing the ratio muscle - connective tissue Group 3: - Degree of (dys)function of the mandible with objective (mandibular opening in mm, description of craniofacial and dental occlusions) and subjective measures (MFIQ) - sEMG of the submental muscle group during swallowing of thin liquid, semi solid and solid food with different head postures (duration (in sec) and amplitude (in µV )) - Dysphagia limit (in sec) - Maximal tongue pressure (in mmHg) during swallowing of thin liquid, semi solid and solid food - Echodensity of the tongue structure and muscle thickness representing the ratio muscle - fibrous tissue	—

Measure

Time frame

Group 1 and 2: - Complaints and symptoms of swallowing problems - Degree of (dys)function of the mandible with objective (mandibular opening in mm, description of craniofacial and dental occlusions) and subjective measures (MFIQ) - sEMG of the submental muscle group during swallowing of thin liquid, semi solid and solid food with different head postures (duration (in sec) and amplitude (in µV )) - Dysphagia limit (in sec) - Maximal tongue pressure (in mmHg) during swallowing of thin liquid, semi solid and solid food - Information of the oral, pharyngeal and esophageal phase of swallowing from the videofluoroscopic swallow study - Echo density of the tongue structure and muscle thickness representing the ratio muscle - connective tissue Group 3: - Degree of (dys)function of the mandible with objective (mandibular opening in mm, description of craniofacial and dental occlusions) and subjective measures (MFIQ) - sEMG of the submental muscle group during swallowing of thin liquid, semi solid and solid food with different head postures (duration (in sec) and amplitude (in µV )) - Dysphagia limit (in sec) - Maximal tongue pressure (in mmHg) during swallowing of thin liquid, semi solid and solid food - Echodensity of the tongue structure and muscle thickness representing the ratio muscle - fibrous tissue

—

Secondary

Measure	Time frame
0	—

Countries

Netherlands

Outcome results