Nocturnal protein supply during sleep as a dietary strategy to improve muscle mass in elderly

Nocturnal protein supply during sleep as a dietary strategy to improve muscle mass in elderly - Nocturnal protein supply

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34886

Enrollment

Registered

2010-06-04

Start date

2010-06-30

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spieropbouw bij ouderdom muscle loss sarcopenia

Interventions

At 02.00 h, half of the subjects will receive a bolus of protein beverage by their nasogastric tube. The same protein as has been used previously [MEC 07-3-086], will be used in this study. Subjects

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male 65-80 yr of age no medication BMI

Exclusion criteria

Exclusion criteria: Comorbidities associated with muscle metabolism

Design outcomes

Primary

Measure	Time frame
The primary endpoint will be muscle protein synthesis. Muscle protein synthesis will be calculated by differences in plasma and muscle tracer enrichments. Phenylalanine and tyrosine enrichment in plasma samples and in the muscle free amino acid pool will be measured using gas chromatography-mass spectrometry, while the phenylalanine enrichment in muscle proteins will be measured with GC-combustion IRMS. We measure muscle protein synthesis after nocturnal protein ingestion by nasogastric tube.	—

Measure

Time frame

The primary endpoint will be muscle protein synthesis. Muscle protein synthesis will be calculated by differences in plasma and muscle tracer enrichments. Phenylalanine and tyrosine enrichment in plasma samples and in the muscle free amino acid pool will be measured using gas chromatography-mass spectrometry, while the phenylalanine enrichment in muscle proteins will be measured with GC-combustion IRMS. We measure muscle protein synthesis after nocturnal protein ingestion by nasogastric tube.

—

Secondary

Measure	Time frame
None.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)